§ 01 · Introduction
The H. pylori Investigation Series

H. pylori is typically investigated for one condition.
The literature documents eight.

An estimated 1 in 3 Americans may carry H. pylori. Most are never investigated beyond digestive complaints.

Peer-reviewed citations Evidence graded · 3 tiers Commercial interest disclosed
welyon.com / 2026
A diagnostic investigation series
§ 02 · Diagnostic gap
What the research shows

A common bacterium. An uncommonly narrow workup.

The standard workup screens H. pylori only when the symptom is digestive. The peer-reviewed literature documents associations across eight conditions — most of which are never tested for it.

1 in 3
Americans may carry it

Most are asymptomatic and never tested — the carrier rate is the rule, not the exception.

Cite · CDC · Hooi et al. 2017
8
Documented conditions

From refractory iron deficiency to chronic urticaria — each with peer-reviewed association literature.

See · The investigation series ↓
4
Mechanisms, all investigable

Acid suppression, nutrient malabsorption, chronic inflammation, molecular mimicry.

Methods · Foundation Protocol
Evidence grading
Strong 3 conditions
Moderate 4 conditions
Exploratory 1 condition

Each guide tags its evidence tier on the cover and inside.

§ 03 · The investigation series
The investigation series · Eight guides

Find the condition. Read the investigation.

Each guide unpacks the mechanism, the standard workup's blind spot, and the diagnostic steps to rule H. pylori in or out. PDF download via Lemon Squeezy — no subscription, no upsell, no membership wall.

Guide № 01 · Iron Deficiency

Why your iron won't budge

Refractory iron deficiency in adults who absorb fine on paper — what the standard workup overlooks.

Strong evidence Get the Guide
Guide № 02 · Chronic Fatigue

The fatigue nobody can name

Unexplained, post-exertional, "all-labs-normal" fatigue — and the gastric pathway worth ruling out.

Moderate evidence Get the Guide
Guide № 03 · Brain Fog

The brain fog investigation

Cognitive symptoms with no structural finding — vitamin pathways, inflammation, and the gut–brain axis.

Moderate evidence Get the Guide
Guide № 04 · Thyroid

The thyroid–stomach connection

Hashimoto's autoimmunity and the molecular-mimicry hypothesis — the evidence base, plainly graded.

Moderate evidence Get the Guide
Guide № 05 · Chronic Hives

When the hives won't stop

Chronic spontaneous urticaria and the mast cell axis — what an allergist might not order.

Moderate evidence Get the Guide
Guide № 06 · Metabolic

The metabolic question

Insulin signalling, inflammation, and the case for a gastric workup before the next medication trial.

Exploratory Get the Guide
Guide № 07 · B12 Deficiency

B12 that won't hold

Low B12 in adults who are supplementing — intrinsic factor, atrophic gastritis, and the workup most miss.

Strong evidence Get the Guide
Guide № 08 · Rosacea

The rosacea workup

Vasoactive peptides, telangiectasia, and a peer-reviewed link the dermatology workup rarely tests for.

Strong evidence Get the Guide
§ 04 · Free overview
Free · No paywall

Not sure which guide is yours?

Start with the H. Pylori Overview — a free guide to the diagnostic gap, the four mechanisms, and which conditions to investigate first. PDF, eighteen pages, no upsell.

§ 05 · How it works
Test → Investigate → Protocol

A protocol with a diagnostic step, not a guess.

Welyon's investigation is sequenced like a clinical workup. Test for the organism. Read the relevant guide. Engage the supervised protocol — only if indicated.

Step 01

Test at home

A non-invasive at-home stool antigen test — the same test gastroenterologists order. Mailed back in the prepaid pouch; results in 5–7 days.

CLIA-certified lab · Antigen detection
Order the kit · $79
Step 02

Read the investigation

Match your symptom to one of eight condition guides. Each grades the evidence, names the mechanism, and lists the next clinical questions to bring to a physician.

Peer-reviewed · Evidence-graded
Step 03

Engage the Foundation Protocol

If the test returns positive and the guide is relevant, you're routed toward a physician-supervised treatment protocol (in development) — eradication, follow-up testing, and condition-specific monitoring.

Physician-supervised · US licensed
Read the full process — including what happens if the test is negative
§ 06 · Credibility
How Welyon shows its work

Skeptic-first. By design.

A research brand has to be auditable. These are the four artifacts that, together, separate Welyon from a wellness pitch: an advisory board, a registered trial, an evidence grading rubric, and a clear commercial interest disclosure.

Scientific Advisory Board

Clinicians and researchers, named publicly

Welyon is assembling a scientific advisory board with expertise in gastroenterology, infectious disease, and evidence-based medicine. Advisor names and affiliations will be listed here upon confirmation.

In formation · 2026
ClinicalTrials.gov

A registered trial, before launch

The Foundation Protocol will be registered on ClinicalTrials.gov prior to commercial availability. Registration ID will appear here, alongside the primary endpoints and the pre-registered analysis plan.

Registration pending
Evidence grading

Three tiers, plainly labelled

Every claim across the eight guides is tagged with one of three evidence tiers, defined transparently below. No claim leaves a guide ungraded.

Strong Multiple peer-reviewed studies in agreement; replicated in independent cohorts.
Moderate Consistent literature, but cohorts are limited or mechanism is partially characterised.
Exploratory Plausible mechanism with early-stage evidence; the case for investigating, not concluding.
Commercial interest

What Welyon sells

Welyon is developing an at-home H. pylori testing kit and a physician-supervised protocol. The presence of this disclosure does not change the content of the guides. We disclose this on every guide cover, every checkout page, and in the footer of this site.

Disclosed · Every surface
§ 07 · For practitioners
For practitioners

Are you a clinician?

A separate page covers the test specifications, the supervised protocol's clinical scaffolding, the evidence base in long form, and the partnership model for primary care, GI, dermatology, and rheumatology practices considering an investigation referral pathway.

View practitioner page