You were right to keep looking.
You're not imagining it. The workup just hasn't gone far enough yet.
Three specialists. Three treatment plans. Nobody has investigated the common cause.
- You have ITP and have never been tested for H. pylori as part of your workup
- Your platelet count has been managed with medication but never fully explained
- You have Hashimoto's or Graves' and your TPO antibodies remain elevated despite treatment
- You have chronic urticaria that returns every time antihistamines stop
- You have more than one of these conditions and no physician has asked what they share
- You want to understand the molecular mimicry mechanism before your next specialist appointment
- Easy bruising or tiny red spots (petechiae) for no clear reason
- A platelet count that swings or needs ongoing medication
- ITP with no identified trigger
- Thyroid antibodies still high despite treatment
- Fatigue that persists despite a normal TSH
- Hashimoto's with no family history or trigger
- Hives with no identifiable trigger
- Antihistamines that suppress but don't resolve them
- Hives alongside ITP or thyroid autoimmunity
A workup for the autoimmune condition that nobody connected.
This guide is written for the patient with ITP, thyroid autoimmunity, or chronic urticaria — or more than one — whose workup has treated each condition separately. It maps one molecular mechanism that connects all three through a single upstream source, and gives a sequenced plan for what to investigate next.
It is not a treatment protocol. It's the investigation itself, written down — so your next move is far more specific than your last, whether you take it to your specialists or pursue it on your own.
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i.
The molecular mimicry mechanism — how it worksHow H. pylori's CagA protein generates cross-reactive antibodies, and why the same mechanism can produce different autoimmune conditions in different patients.
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ii.
ITP — the guideline-backed linkWhy hematology guidelines recommend H. pylori testing, what "about half respond" means in practice, and what to say at your next appointment.
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iii.
Thyroid autoimmunity — the linkWhy carriers are about twice as likely to have autoimmune thyroid disease, and what antibody changes to watch for after testing.
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iv.
Chronic hives — what the trials showAcross randomized trials, hives went into remission far more often after the infection was cleared — and how that mirrors the ITP mechanism.
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v.
Condition-specific baselines before any interventionPlatelet count, TPO antibodies, UAS7 score — how to document your before-and-after comparison for all three conditions from a single investigation.
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vi.
Testing options for H. pyloriStool antigen, urea breath test, biopsy — trade-offs, costs, and what each rules in or out across all three conditions.
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vii.
Specialist-specific conversation scriptsLanguage for the specialists who manage these conditions — condition-specific, evidence-grounded, and designed for a single visit each.
Sharper thinking. Clearer next steps.
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Understand the one shared mechanism — how antibodies the body makes against H. pylori can attack platelets, thyroid tissue, and the cells behind hives through the same cross-reaction.
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Know the ITP link in full — why hematology guidelines recommend testing, what "about half respond" means in practice, and what to say at your next appointment.
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Walk away with a single plan across specialties — with a doctor or on your own — including a simple baseline to track for each condition before and after.
Three tiers. One rubric. No exceptions.
Every claim is tagged Strong, Moderate, or Exploratory — so you can see exactly how solid each one is. ITP is the strongest link of the three; thyroid and hives are real but more modest.
Immune / ITP & autoimmunity · evidence summary
A few honest questions.
Is this medical advice?
No. This guide is educational — written to help you understand the evidence, evaluate testing options, and identify questions worth exploring with your healthcare team or on your own.
Why isn't my hematologist already testing for this?
Even though hematology guidelines recommend it, many hematologists don't consistently test for H. pylori in ITP — the recommendation is relatively recent and takes time to filter into everyday practice. It's not a failing on your part. Citing the guideline directly is the most effective way to raise it, and the guide gives you that language — whether you raise it with a doctor or pursue testing yourself.
Do I need to buy the testing kit?
No — the guide is sold separately from any test or product. It covers all three testing options — stool antigen, urea breath test, biopsy — what each costs, and how to ask for it. But a test only tells you yes or no; the guide is what tells you which test to request and what to do with the result, which is where most people get stuck.
What if my labs are 'in range'?
The guide spends a section on this exact situation — what 'in range' obscures, what to look at in combination, and the secondary markers that frequently shift the picture without changing the headline numbers.
Refund policy?
14 days, no questions. If the guide isn't useful, the Lemon Squeezy receipt has a one-click refund link.
Who wrote it?
Researched, written, and medically reviewed by a physician on the Welyon team. Every claim is drawn from peer-reviewed literature and graded inline — Strong, Moderate, or Exploratory — so you can weigh the evidence behind each one yourself.
Start closing the gap between 'normal' and 'explained.'
Move from ruled out to figured out.
40 pages, ten citations, three targets, one clearer next step.
Many readers find more than one guide applies. Each is sold separately — or ask about bundle pricing at checkout.